Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

Abstract Evidence in support of the neuroprotective effects of flavonoids has increased significantly in recent years, although to date much of this evidence has emerged from animal rather than human studies. Nonetheless, with a view to making recommendations for future good practice, we review 15 existing human dietary intervention studies that have examined the effects […]

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Improvement of cognitive functions by oral intake of Hericium erinaceus

Abstract Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body of H. erinaceus for 12 weeks. […]

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What is Mesima?

Mesima is the substance to enhance the anti-cancer immunological activities containing protein bounded polysaccharide (PPLA) that is obtained in the process to massively cultivate, extract and refine pure mycelium from fruit body of Phellinus linteus that is called as Sang-Hwang (galenical name) that is a kind of mushroom. The research team of Dr. Chihara in […]

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The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma

Abstract The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest. However, whether medina also facilitates treatment of hepatocellular carcinoma (HCC), the third global cause of cancer deaths, remains unknown. Here, we examined […]

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Enhanced Mycelium Production of Phellinus igniarius (Agaricomycetes) Using a He-Ne Laser with Pulsed Light

Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers. <i>Phellinus linteus</i> is a well-known Oriental medicinal fungus with a variety of biological activities, including immunomodulatory or direct antitumor activities. The […]

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Antitumor and Antioxidant Activities of the Extracts from Fruiting Body of Phellinus linteus

Abstract Fruiting bodies of Phellinus linteus were extracted by hot water and alkali methods. Sugar contents of PL-H (hot water extract) and PL-A (alkali water extract) were 81.1%, 37.4% and protein contents were 6.2%, 21.8%, respectively. Amino acid pattern showed that two extracts contained large amount of aspartic acid and alanine. Two extracts showed characteristic IR absorption […]

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