March 2022 - Medicinal Mushroom Clinical Research, News and Recipes

Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation

March 31, 2022March 31, 2022Ijaz

Abstract In the present study, the role of Tremella polysaccharides in cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide (LPS) in human epithelial A549 lung-cancer cells was investigated. Initially, it was demonstrated that LPS attenuated A549 cell viability in a time- and dose-dependent manner. Furthermore, LPS induced apoptotic cell death and autophagy in A549 cells and increased reactive […]

The hypocholesterolemic effect of two edible mushrooms: Auricularia auricula (tree-ear) and Tremella fuciformis (white jelly-leaf) in hypercholesterolemic rats

March 31, 2022March 31, 2022Ijaz

Abstract The effect of two edible mushrooms, namely Auricularia auricula (Tree-ear) and Tremella fuciformis (White jelly-leaf) of the Heterobasidiae, on serum and liver lipids, fecal neutral steroids and bile acid excretion was investigated in rats. Male Sprague-Dawley rats were fed two semisynthetic hypercholesterolemic diets (1.5% cholesterol, 5% fat) each containing 5% dried powder of the two mushrooms. After 4 wk […]

Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1

March 31, 2022July 4, 2022Ijaz

Abstract Tremella fuciformis polysaccharide (TFPS), which is the extract of Tremella fuciformis Berk, has previously been demonstrated to exhibit potent anti-oxidative, anti-inflammatory and anti-aging effects. However, the mechanisms underlying these protective and therapeutic effects remain to be elucidated. The aim of the present study was to investigate the protective effects of TFPS on hydrogen peroxide-induced injury of human […]

Tremella fuciformis Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155

March 31, 2022March 31, 2022Ijaz

Abstract Aim: To investigate the function of Tremella fuciformis polysaccharides (TFPS) in LPS-induced inflammation and oxidative stress of macrophages. Methods: RAW264.7 cells were pretreated with TFPS and then stimulated with 0.1 μg/ml LPS. NFκB, Akt, p38MAPK, MCP-1, and SOD-1 were analyzed by Western blotting. Cell viability was measured using MTT assays. Reactive oxygen species (ROS) production, real-time PCR, ELISA, and […]

Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

March 28, 2022March 28, 2022Ijaz

Abstract Evidence in support of the neuroprotective effects of flavonoids has increased significantly in recent years, although to date much of this evidence has emerged from animal rather than human studies. Nonetheless, with a view to making recommendations for future good practice, we review 15 existing human dietary intervention studies that have examined the effects […]

Improvement of cognitive functions by oral intake of Hericium erinaceus

March 28, 2022March 28, 2022Ijaz

Abstract Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body of H. erinaceus for 12 weeks. […]

What is Mesima?

March 28, 2022March 28, 2022Ijaz

Mesima is the substance to enhance the anti-cancer immunological activities containing protein bounded polysaccharide (PPLA) that is obtained in the process to massively cultivate, extract and refine pure mycelium from fruit body of Phellinus linteus that is called as Sang-Hwang (galenical name) that is a kind of mushroom. The research team of Dr. Chihara in […]

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma

March 28, 2022March 28, 2022Ijaz

Abstract The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest. However, whether medina also facilitates treatment of hepatocellular carcinoma (HCC), the third global cause of cancer deaths, remains unknown. Here, we examined […]

Black Hoof Mushroom – Uses, Side Effects, and More

March 28, 2022March 28, 2022Ijaz

Black hoof mushroom (Phellinus linteus) is an orange mushroom that grows on mulberry trees. It has been used as medicine for centuries in Japan, Korea, and China.Chemicals in black hoof mushroom might block allergic reactions, prevent the growth of bacteria, and protect the liver from toxins. These chemicals might also increase the activity of the […]

Enhanced Mycelium Production of Phellinus igniarius (Agaricomycetes) Using a He-Ne Laser with Pulsed Light

March 28, 2022March 28, 2022Ijaz

Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers. <i>Phellinus linteus</i> is a well-known Oriental medicinal fungus with a variety of biological activities, including immunomodulatory or direct antitumor activities. The […]