Oxidative stress Archives - Medicinal Mushroom Clinical Research, News and Recipes

Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2-antioxidant mechanism to exert anti-skin aging effects in human dermal fibroblasts

March 26, 2022July 4, 2022Ijaz

Abstract Oxidative stress is a major cause of aging related skin injuries. Hydrogen peroxide related ROS accumulation triggers increase in matrix metalloproteinases and elevated collagen degradation, which is a characteristic of skin aging. In this study, we investigated the protective effect of Poria cocos, used widely in the treatment of inflammatory diseases, against H2 O2 induced oxidative […]

Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice

March 11, 2022March 11, 2022Ijaz

Abstract Lung fibrosis is a chronic and intermittent pulmonary disease, caused by damage to the lung parenchyma due to inflammation and fibrosis. Epicatechin (Epi) as a flavonoid has antioxidant and anti-inflammatory properties. This study was conducted to evaluate the effect of Epi on oxidative stress, inflammation and pulmonary fibrosis induced by bleomycin (BLM) in mice. […]