Shiitake Archives - Medicinal Mushroom Clinical Research, News and Recipes

Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism

October 29, 2023October 29, 2023Ijaz

Abstract Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer’s and Parkinson’s diseases. Therefore, efforts have been devoted to a search for […]

Shiitake Mushrooms: Health Benefits, Nutrition, and Uses

April 27, 2022April 27, 2022Ijaz

Shiitake mushrooms have a rich, earthy flavor and a distinctive taste best described as meaty. These mushrooms have large caps measuring 2 to 5 inches wide, and they vary in color from light to chocolate brown, providing an attractive contrast with their pale cream underside. Lentinula edodes is native to the mountain regions of Japan, Korea, […]

Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet

April 27, 2022April 27, 2022Ijaz

Abstract High-fat diet (HFD) induces obesity. This study examined the effects of Shiitake mushroom on the prevention of alterations of plasma lipid profiles, fat deposition, energy efficiency, and body fat index induced by HFD. Rats were given a low, medium, and high (7, 20, 60 g/kg = LD-M, MD-M, HD-M) Shiitake mushroom powder in their high-fat […]

A High-Dose Shiitake Mushroom Increases Hepatic Accumulation of Triacylglycerol in Rats Fed a High-Fat Diet: Underlying Mechanism

April 27, 2022April 27, 2022Ijaz

Abstract Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet (HFD). Forty Wistar rats […]

Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

April 27, 2022April 27, 2022Ijaz

Abstract Fulminant hepatic failure (FHF) is a rare, life-threatening liver disease with a poor prognosis. Administration of D-galactosamine (GalN) and lipopolysaccharide (LPS) triggers acute liver injury in mice, simulating many clinical features of FHF in humans; therefore, this disease model is often used to investigate potential therapeutic interventions to treat FHF. Recently, suppression of the […]

Lentinus edodes promotes fat removal in hypercholesterolemic mice

April 26, 2022April 26, 2022Ijaz

Abstract Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phospholipid metabolism. In the present study, the effects of […]

Effect of Various Mushroom Preparations on Cholesterol Levels in Rats

April 26, 2022April 26, 2022Ijaz

Abstract To evaluate the effect of mushrooms on cholesterol metabolism, rats were fed, ad libitum, for 10 weeks a diet containing 5% of ground dried mushroom (Lentinus edodes, Kohshin) with or without exogenous cholesterol. The results indicate that the dried mushroom preparation markedly reduced plasma cholesterol levels. In further experiments, some other species of mushrooms […]

Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats

April 26, 2022April 26, 2022Ijaz

Abstract We investigated diet supplementation with shiitake mushroom fruiting bodies on biochemical and histological changes in hypercholesterolemic rats. Six-wk old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. A diet containing 5% Lentinus edodes fruiting bodies given to hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein (LDL), total lipid, phospholipids, and […]

Diets Containing Shiitake Mushroom Reduce Serum Lipids and Serum Lipophilic Antioxidant Capacity in Rats

April 26, 2022April 26, 2022Ijaz

Background: We previously reported that dietary intake of shiitake mushroom (SM; Lentinus edodes) decreased serum concentrations of polar lipids in male rats. Objective: This study evaluated the dietary effects of SM on serum cholesterol–related and serum antioxidant indexes in rats of both sexes. Methods: Sprague-Dawley rats [38 dams and their offspring (20 males and 20 females/diet)] were fed diets […]

Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms

April 26, 2022April 26, 2022Ijaz

Abstract Objective: Shiitake (Lentinus edodes) mushrooms have been reported to have cancer-preventing properties. However, little research has been conducted verifying the antitumor activities of “mycochemicals” in shiitake mushrooms. In this study, potential roles of an ethyl acetate fraction from shiitake mushrooms were investigated by in vitro bioassays. Design: The activities of an ethyl acetate fraction were evaluated […]