Poria Archives - Medicinal Mushroom Clinical Research, News and Recipes

Chapter Twelve – Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in China

March 26, 2022March 26, 2022Ijaz

Abstract Poria cocos is an edible mushroom known as “Fuling” in Chinese, which belongs to the fungus family of Polyporaceae. Poria cocos has been used as a Chinese traditional medicine for > 2000 years. Indications for using it include promoting urination, to invigorate the spleen function, and to calm the mind. The bioactive components in Poria cocos include polysaccharides, triterpenoids, fatty acids, sterols, enzymes, etc. Poria […]

Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7

March 26, 2022March 26, 2022Ijaz

Abstract Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and […]

Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism

March 26, 2022March 26, 2022Ijaz

Abstract Ethnopharmacological relevance: Poria cocos Wolf (P. cocos), a well-known traditional East-Asian medicinal and edible fungus, is one of the most important components in Chinese medicine formulas like “Guizhi fuling wan” to treat hyperplasia of mammary glands and breast cancer. Aiming of study: In this study, we attempted to verify the anticancer efficacy of the ethanol extract […]

Anti-inflammatory activity of the sclerotia of edible fungus, Poria cocos Wolf and their active lanostane triterpenoids

March 26, 2022March 26, 2022Ijaz

Highlights Fourteen lanostane triterpenoids were identified from the sclerotia of edible fungus Poria cocos. Four new lanostane triterpenoids (1–4) were structurally elucidated. Compounds 8 and 13 were isolated for the first time from P. cocos. Compounds 1, 2, 6, 12, and 14 inhibited NO production in LPS-activated RAW264.7 macrophages. The mechanism of action for the most active compound 14 was examined. Abstract Poria cocos Wolf confers large, edible sclerotia, known as ‘Indian bread’ in […]

Chemical constituents and pharmacological properties of Poria cocos

March 26, 2022March 26, 2022Ijaz

Abstract Poria cocos (Polyporaceae) is a saprophytic fungus that grows in diverse species of Pinus. Its sclerotium, called fu-ling or hoelen, is used in traditional Chinese and Japanese medicine for its diuretic, sedative, and tonic effects. Various studies of this fungus have demonstrated its marked anti-inflammatory activity in different experimental models of acute and chronic […]

Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis

March 26, 2022March 26, 2022Ijaz

Abstract Objective: In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model. Methods: The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations […]

Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

March 26, 2022March 26, 2022Ijaz

Background Poria cocos Wolf, a medicinal fungus, is widely used in traditional medicines in East Asian countries owing to its various therapeutic potentials. Although several studies have demonstrated the anti-inflammatory activity of this fungus, its underlying mechanisms have not yet been clearly defined. Methods In the present study, we have demonstrated the anti-inflammatory effects of ethanol […]

Medicinal mushroom Phellinus linteus as an alternative cancer therapy

March 26, 2022March 26, 2022Ijaz

Abstract Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers. Phellinus linteus is a well-known Oriental medicinal fungus with a variety of biological activities, including immunomodulatory or direct antitumor activities. The activity […]

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma

March 26, 2022March 26, 2022Ijaz

Abstract The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest. However, whether medina also facilitates treatment of hepatocellular carcinoma (HCC), the third global cause of cancer deaths, remains unknown. Here, we […]

The Evaluation of Antioxidant, Anti-inflammatory, and Anti-aging of Extract Solvent and Poria cocos by Parts

March 26, 2022March 26, 2022Ijaz

ABSTRACT This study is for checking the possibility of Poria cocos as cosmetic materials. For this we carried out biological active evaluation about antioxidant, anti-inflammatory and anti-aging by using extraction parts of Poria cocos and solvent extraction. We extracted Poria cocos by extraction parts (bark, inside skin) and solvents (water extracts, ethanol), and then in […]