Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells

Cordyceps sinensis, an edible mushroom growing in Himalayan regions, is widely recognized in traditional system of medicine. In the present study, we report the efficacy of Cordyceps sinensis in facilitating tolerance to hypoxia using A549 cell line as a model system. Treatment with aqueous extract of Cordyceps sinensis appreciably attenuated hypoxia induced ROS generation, oxidation of lipids and proteins […]

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Does Cordyceps sinensis Ingestion Aid Athletic Performance?

Abstract summary  Cordyceps sinensis is a potentially ergogenic herb that gained popularity after the Chinese women’s team credited it for their world-record performances at the 1993 World Track and Field Championships. Since then, a few peer-reviewed investigations have been published, but results of these investigations have been equivocal, with two human studies claiming an ergogenic […]

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Cordyceps as an Herbal Drug

5.1. INTRODUCTION Cordyceps is the composite of a genus of fungus that grows on the larva of insects. To date, more than 350 Cordyceps-related species have been found worldwide based on fungus and/or insect host. However, since 1964, only Cordyceps sinensis has been recorded officially as an herbal drug in Chinese pharmacopoeia. C. sinensis, known as Dongchongxiacao (winter-worm summer-grass) in Chinese, is one […]

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Cordyceps Libido and Erectile Function

Cordyceps has been used for centuries by traditional Chinese medicine to help with sexual dysfunction. Preclinical data on the effects of Cordyceps on mice showed sex steroid-like effects. (Holliday, J. et al. On the Trial of The Yak Ancient Cordyceps in the Modern World. 2004) The results of human clinical trials published in The Journal Of […]

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Cordyceps as an Herbal Drug

Cordyceps is the composite of a genus of fungus that grows on the larva of insects. To date, more than 350 Cordyceps-related species have been found worldwide based on fungus and/or insect host. However, since 1964, only Cordyceps sinensis has been recorded officially as an herbal drug in Chinese pharmacopoeia. C. sinensis, known as Dongchongxiacao (winter-worm summer-grass) in Chinese, is one of the […]

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Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation

Abstract To determine the effects of a mushroom blend containing cordyceps militaris on high intensity exercise after 1- and 3-weeks of supplementation. Twenty-eight individuals (Mean ± SD; Age=22.7 ± 4.1 yrs; Height=175.4 ± 8.7 cm; Weight=71.6 ± 12.0 kg) participated in this randomized, repeated measures, double-blind, placebo-controlled design. Maximal oxygen consumption (VO2max), time to exhaustion […]

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Effects of the Immunomodulatory Agent Cordyceps militaris on Airway Inflammation in a Mouse Asthma Model

Background Cordyceps militaris is a well-known fungus with immunomodulatory activity. It is generally used in traditional Chinese medicine to treat hemoptysis, bronchial or lung inflammation, and urogenital disorders. The purpose of our study was to evaluate the effect of cultivated C. militaris on airway inflammation in a mouse asthma model. Methods BALB/c mice were sensitized with intraperitoneal ovalbumin […]

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Effectiveness and Safety of Oral Cordyceps sinensis on Stable COPD of GOLD Stages 2–3: Systematic Review and Meta-Analysis

Abstract Cordyceps sinensis (CS) is a complementary medicine used for Chronic Obstructive Pulmonary Disease (COPD) of Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 2-3. Many randomized controlled trials have been conducted to evaluate the effect of CS alone or in combination with other herbs on stable COPD. To provide a synthesis of the evidence, […]

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Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease

Cordyceps sinensis is a traditional Chinese herbal medicine that has been used for centuries in Asia as a tonic to soothe the lung for the treatment of respiratory diseases. The aim of the present study was to determine the effects of C. sinensis on airway remodeling in chronic obstructive pulmonary disease (COPD) and investigate the underlying molecular […]

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