Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis

Abstract Objective: In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model. Methods: The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations […]

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Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages

Background Poria cocos Wolf, a medicinal fungus, is widely used in traditional medicines in East Asian countries owing to its various therapeutic potentials. Although several studies have demonstrated the anti-inflammatory activity of this fungus, its underlying mechanisms have not yet been clearly defined. Methods In the present study, we have demonstrated the anti-inflammatory effects of ethanol […]

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Inonotus obliquus attenuates histamine-induced microvascular inflammation

Sumreen Javed, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing,1,‡ Kevin Mitchell, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing,2,‡ Danielle Sidsworth, Data curation, Methodology, Writing – review & editing,2 Stephanie L. Sellers, Writing – review & editing,3 Jennifer Reutens-Hernandez, Data […]

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Chaga: Are There Health Benefits?

The chaga mushroom, or Inonotus obliquus, is a large, black fungus thought by many to have medicinal properties. Native to cooler northern regions of Asia, Europe, and North America, the Chaga mushroom grows mainly on birch trees. Because chaga has a very high melanin content, its exterior will turn a deep black color when exposed to […]

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